Description
Product Characteristics:
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-, as well as 'Lys-63'-linked polyubiquitination. Participates in the regulation of transepithelial sodium transport in renal cells. May be involved in cell growth arrest.
Subcellular location: Cytoplasm, Nucleus
Synonyms: Homologous to yeast UBC4/5, UB2E3_HUMAN, UBC E4, Ubc M2, UBC4/5 homolog, UBCE 4, UBCE4, UBCH 9, UBCH9, UbcM2, UBE2 E3, UBE2E3, Ubiquitin carrier protein, Ubiquitin carrier protein E3, Ubiquitin conjugating enzyme E2 23 kDa, Ubiquitin conjugating enzyme E2 E3, Ubiquitin conjugating enzyme E2E 3, Ubiquitin conjugating enzyme UBCH 9, Ubiquitin conjugating enzyme UBCH9, Ubiquitin protein ligase, Ubiquitin protein ligase E3, Ubiquitin-conjugating enzyme E2 E3, Ubiquitin-conjugating enzyme E2-23 kDa, Ubiquitin-protein ligase E3.
Target Information: The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein shares 100% sequence identity with the mouse and rat counterparts, which indicates that this enzyme is highly conserved in eukaryotes. Two alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]